[Belma Technologies] E2-R-17β-estradiol 30 days

[Belma Technologies] Implants Estradiol

[Belma Technologies] E2-R-17β-estradiol 30 days

Correlation between in vitro and in vivo measurements in the rat.

Description:

• Implants designed to release daily doses of oestradiol to produce physiological plasma concentrations in rats and mice. (The normal values of oestradiol in these rodents are between 2.4 and 145.4 pg/ml.)
• Excellent correlation between the in vitro diffusion values and plasma concentrations.
• Extremely small inter-implant variations and constant hormone release.
• Doses chosen to promote hormone-dependent tumour cell growth in murine models.
• The amount of oestradiol released over 24 hours makes it possible to achieve plasma concentrations corresponding to the pre-ovulatory stage. These physiological conditions are sufficient to stimulate tumour growth whilst limiting the renal problems (crystals in the bladder) that are commonly seen with overly high oestradiol doses.